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how can I draw fischer projections from wedge and dash?

Aniket Singh , 10 Months ago
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Askiitians Tutor Team

Converting wedge-and-dash representations to Fischer projections involves a few steps. Fischer projections are a way to represent chiral molecules in a two-dimensional format, which is especially useful for carbohydrates and amino acids. To convert a wedge-and-dash structure to a Fischer projection, follow these steps:

Identify the Chiral Center:

Locate the carbon atom that is chiral (tetrahedral) in the molecule. This carbon atom is typically the one bonded to four different substituents.
Determine the Priority of Substituents:

Assign priority to the substituents attached to the chiral carbon using the Cahn-Ingold-Prelog (CIP) rules. Priority is determined based on the atomic number of the atoms directly bonded to the chiral carbon. The higher the atomic number, the higher the priority.
If there are two substituents with the same atom attached to the chiral carbon, prioritize them based on the next atoms in their respective chains.
Orient the Substituents:

Arrange the substituents around the chiral carbon so that the lowest-priority group (often a hydrogen atom) points backward into the plane of the paper or screen. This is represented with a horizontal line in a Fischer projection.
The remaining three substituents (highest to lowest priority) will be oriented vertically above or below the chiral carbon.
Draw the Fischer Projection:

Draw a vertical line to represent the chiral carbon's backbone.
Place the substituents above and below the vertical line according to their priorities.
If the molecule is in a wedge-and-dash representation, the substituents that were originally coming out of the plane (wedges) should be placed above the horizontal line in the Fischer projection, and those going into the plane (dashes) should be placed below the horizontal line.
Verify the Configuration:

Make sure that the arrangement of substituents in the Fischer projection matches the spatial arrangement in the original molecule.

Last Activity: 10 Months ago
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