Flag Organic Chemistry> amino acid...
question mark

write the methods of preparation of amino acid.

nikulas saikia , 12 Years ago
Grade
anser 2 Answers
Aman Bansal

Last Activity: 12 Years ago

Dear Nikulas,

Methods of preparation of amino acids:         

 
 

(i)            Elimination of α - haloacids.

 
 
      Cl – CH2COOH + 2NH3 ———> H2NCH2COOH + NH4Cl
                                                           Glycine
 
 

(ii)          Gabriel phthalimide synthesis:

 

α halogenated acid or ester combines with potassium phthalimide. Product on hydrolysis gives α - amino acid.

 

90_Phthalic acid.JPG           

 

(iii) Knoop synthesis:

 

α - keto acid on treatment with NH3 forms an imine which on catalytic reduction gives amino acid.

 

      479_Pyruric acid.JPG

 

(iv) Strecker synthesis:

 

Aldehydes react with HCN and ammonia or NH4CN and the product on hydrolysis yields α - aminoacids.

 

 

        H                               H                                     H                                 H
        |          HCN                |                   NH3              |             H2O.H+           |
R — C = O ———> R —— C —— OH ———> R —— C — NH2 ———> R —— C —— NH2
 
 
                                         |                                       |                                   |
     Aldehyde                    CN                                   CN                             COOH
                                 Cyanohydrin                       Aminonitrile                 α - amino acid

 

 

Some of the reactions given by amino acids are as follows:

 

               2357_Amino acid reaction.JPG

Best Of Luck...!!!!

Cracking IIT just got more exciting,It’s not just all about getting assistance from IITians, alongside Target Achievement and Rewards play an important role. ASKIITIANS has it all for you, wherein you get assistance only from IITians for your preparation and win by answering queries in the discussion forums. Reward points 5 + 15 for all those who upload their pic and download the ASKIITIANS Toolbar, just a simple  to download the toolbar….

So start the brain storming…. become a leader with Elite Expert League ASKIITIANS

Thanks

Aman Bansal

Askiitian Expert

Rishi Sharma

Last Activity: 4 Years ago

Dear Student,
Please find below the solution to your problem.
Methods of preparation of amino acids:
(i)Elimination of α - haloacids.
645-703_027.PNG
(ii)Gabriel phthalimide synthesis:α-halogenatedacid or ester combines with potassium phthalimide. Product on hydrolysis givesα - amino acid.
645-1236_0027.PNG
(iii)Knoop synthesis:α -keto acid on treatment with NH3forms an imine which on catalytic reduction gives amino acid.
645-991_00027.PNG
Thanks and Regards

Provide a better Answer & Earn Cool Goodies

Enter text here...
star
LIVE ONLINE CLASSES

Prepraring for the competition made easy just by live online class.

tv

Full Live Access

material

Study Material

removal

Live Doubts Solving

assignment

Daily Class Assignments


Ask a Doubt

Get your questions answered by the expert for free

Enter text here...